Aperture
BIIBToplinePhase 3Window

Phase 3 topline — Tofersen

Biogen Inc. · NASDAQ · $33.1B market cap

Bias Score

P(positive outcome)

Forecast move

Date confidence

45%

Company guidance for a period, e.g. 2H 2026.

What this event is

A Study of BIIB067 (Tofersen) Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation

Drug
Tofersen
Mechanism
—
Indication
Amyotrophic Lateral Sclerosis Associated With a SOD1 Gene Mutation
Primary endpoint
Parts B and C: Percentage of Participants with Emergence of Clinically Manifest ALS Within 24 Months of Part B Baseline
Enrollment
158
Source
ClinicalTrials.gov

Full dossier

Aperture

Trial design and what the registration does and does not record, the primary endpoint and how it is assessed, where the date comes from and how firm it is, and the balance-sheet position going into the print.

Aperture unlocks the full dossier on every event — trial design, endpoint, date provenance, balance sheet.

See pricing

How the model got here

Aperture

Aperture unlocks the model's written rationale for each score.

See pricing

Feature attribution

Aperture

Aperture unlocks per-event feature attribution from the model.

See pricing

Two-sided forecast

Aperture

Aperture unlocks the calibrated probability and Bias Score for every event.

See pricing

Company

Market cap
$33.1B
Cash
$2.9B
Runway
—
Approved products
0

Research, not advice. Aperture is not a registered investment adviser or broker-dealer and does not provide personalised recommendations. Nothing here is sized to your circumstances. Trial details come from the sponsor's own ClinicalTrials.gov registration, which sponsors revise; the date is the registered primary completion date, not a commitment.